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24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal INRAE Université de Liège Université de Lille Université Picardie Jules Verne Associated institutions

UMR Transfrontalière BioEcoAgro (

Thesis - Extraction and separation processes

Extraction and separation processes using combined Green Technologies for Seaweed biorefineries

ESTABLISHMENT : University of the Littoral Opal Coast / University of Lille

Laboratories of affiliation : UMRt BioEcoAgro (UMR 1158): Biochemistry of Aquatic Products unit (ULCO) and Charles Viollette Institute (U. Lille)
Scientific field, Speciality: Food Biotechnology, Food Science, Physiology
Thesis director: Professeur Thierry GRARD, PR,
Co-director: Vincent PHALIP, PR,
Co-supervisor (non HDR):
Planned co-funding (in progress) : 50% Pôle Métropolitain Côte d’Opale (PMCO) / 50% ED Sciences de la Matière, du Rayonnement et de l’Environnement (SMRE)

Title of the thesis :
Extraction and separation processes using combined Green Technologies for Seaweed biorefineries

Seaweeds are an underexploited bioresource in Europe despite their potential for the production of a large number of products and high-value biomolecules including proteins, polysaccharides, lipids, and antioxidants. Due to their rigid cell wall and complex composition, implementing extraction and separation processes to diversify their
products is indeed a technological challenge. The valorisation of the whole biomass requires the design of a cascade of processes for a sequential recovery of products following a biorefinery approach. To respond to current societal and environmental needs, green extraction and purification technologies are needed. Combining green
technologies for extraction (enzymes/ultrasound) and separation stages (membrane chromatography) seems a good alternative to conventional or to expensive high-tech methods. This way of process intensification may result in synergies that would improve efficiencies, yields, purities and reduce cost and processing time. In this context,
this project aims to develop and assess combined green processes: enzymes/ultrasound extraction and membrane chromatography, as the main stages of downstream processes of seaweed biorefineries.
The thesis will be carried out in cotutelle between the University of the Littoral Opal Coast (Boulogne-sur-mer) and the University of Lille (Villeneuve d'Ascq).
Required profile :
Holder of a Master (M2) or an engineering degree in the field of process engineering, bioprocesses, biochemistry, agri-food or equivalent, with a very good academic level. Knowledge of extraction (ultrasound, assisted by enzymes, etc.) and separation (membranes, chromatography, etc.) processes is necessary. Experience on biochemical
analysis techniques would be an asset. The candidate must have good experimental skills, good writing and communication skills and must be autonomous and rigorous. Good level of English required.

Expected date of recruitment: 01 September 2023

Application documents: CV, cover letter, official transcript of the last two academic years. English level certificate.

Applications will be accepted until March 31, 2023. Contact details of two references.

Send applications to :